A case of iFOBT-negative CRC in the cecum. A 65-mm CRC was discovered in the cecum of a 56-year-old woman with TCS, despite the fact that her iFOBT had been negative 6 months prior. iFOBT, immunochemical faecal occult blood test; CRC, colorectal cancer; CS, colonoscopy; TCS, total colonoscopy; pSE, CRC infiltrated the serosa pathologically.