Table 1.
Hepatic Injury from Methimazole
| References | Sex/Age | Dose (mg/day) | Duration of Administration | Liver Pathology | Agranulocytosis | Comments | |
|---|---|---|---|---|---|---|---|
| 1. | Spect & Boehme | F/67 | 30 | 30 days | central lobular congestion | + | death due to pneumonia |
| 2. | Rosenbaum & Reveno | F/62 | 10 | 7 weeks | – | + | – |
| 3. | Shipp | F/63 | 60 | 8 weeks | cholestasis | + | – |
| 4. | Tennenbaum & Dresken | F/38 | 60 | 4 weeks | cholestasis | − | skin rash |
| 5. | Lopez et al. | F/38 | 60 | 4 weeks | cholestasis | − | − |
| 6. | Becker et al. | F/54 | 40 | 24 days | focal hepatitis | − | death due to pneumonia |
| 7. | Fisher et al. | F/74 | 40 | 12 days | cholestasis | − | − |
| 8. | Vitug & Goldman | F/64 | 80 | 4 weeks | cholestasis | + | − |
| 9. | Schmidt et al. | F/58 | 20 | 20 days | cholestasis & fatty degeneration | + | − |
| 10. | Kravetz | ?/? | 30–50 | ? | cholestasis | − | − |
| 11. | Knopka et al. | F/37 | ? | ? | ? | ? | − |
| 12. | Manoijlovic | ?/? | 80–100 | ? | ? | + | − |
| 13. | Efstrtiadis | M/50 | 60 | ? | cholestasis | − | − |
| 14. | Sambe | F/30 | 40 | ? | – | − | − |
| 15. | Jansen & Froeling | F/62 | 40 | 5 weeks | cholestasis | − | − |
| 16. | Authors | M/43 | 30 | 17 weeks | cholestasis & focal hepatocellular injury | − | death due to hepatic failure |