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Pdx-1 gene expression in glucose plus metformin group 1 decreased compared with that of the control group 1. Pdx-1 gene expression in glucose plus metformin group 2 significantly decreased compared with that of control group 2 (*P<0.05). The expression of the Pdx-1 gene in treatment group 2 decreased compared with that of treatment group 1. *P<0.05.
