Figure 1.

(a) H and E-stained sections of normal rat liver, no sign of inflammation or necrosis. (b) Liver section of negative control group showing extensive hemorrhagic necrosis particularly around the central vein. (c) Liver section of silymarin (100 mg/kg) treated rats exhibit almost normal hepatic parenchyma with lesser degree of congestion. (d) Section of Karisalai Karpam tablet (50 mg/kg) treated rat liver showing congestion, microvesicular steatosis and congestion of sinusoids but to a lesser extent. (e) Section of Karisalai Karpam tablet (100 mg/kg) treated rat liver showing minimal degree of congestion, no sign of necrosis and portal triads with few inflammatory cells. (f) Liver section of Karisalai Karpam tablet (200 mg/kg) treated rat showing normal hepatic parenchyma with mild congestion of sinusoids