Table II.
Mean LINE-1 and Alu DNA methylation levels and prostate cancer risk
| DNA methylation marker quartilesa | LINE-1 b | DNA methylation marker quartilesa | Alu b | |||
|---|---|---|---|---|---|---|
| Quartile | Range | Case/Control | OR (95% CI)c | Range | Case/Control | OR (95% CI)c |
| Q1 | 63.3-73.0 | 171/182 | REF | 20.5-24.6 | 178/175 | REF |
| Q2 | >73.0-74.1 | 188/178 | 1.16 (0.85-1.57) | >24.6-25.7 | 192/199 | 1.01 (0.74-1.37) |
| Q3 | >74.1-75.3 | 185/177 | 1.10 (0.81-1.50) | >25.7-26.3 | 169/162 | 0.96 (0.70-1.32) |
| Q4 | >75.3-82.9 | 147/163 | 1.01 (0.73-1.39) | >26.3-29.1 | 151/163 | 0.94 (0.68-1.29) |
| ptrendd | 0.99 | ptrendd | 0.69 | |||
a
Defined among controls
b
Average across positions 1-4
c
Adjusted for age at blood draw, year of blood draw, family history of prostate cancer (yes/possible, no), smoking status (never, former, current, pipe/cigar), total folate intake (quartiles), and BMI (<25, 25-29, 30 or higher)
d
Based on a variable assigned the median value (among controls) for each quartile entered as a continuous variable in the model