Table 2. Associations (β-estimates; 95% CI) of markers of mineral metabolism with Telephone Interview of Cognitive Status-modified (TICSm) score.
| Tertile 1 | Tertile 2 | Tertile 3 | Continuous | |
|---|---|---|---|---|
| 25(OH)D | < 13 ng/mL | 13 – 22 ng/mL | 22 ng/mL | Log10 25(OH)D |
| Unadjusted | 0.39 [– 0.63, 1.41] | –0.31 [– 1.31, 0.69] | Ref | –0.79 [–2.48, 0.95] |
| Model 1 | 0.14 [– 0.84, 1.12] | –0.02 [– 0.92, 0.88] | Ref | –0.22 [–1.93, 1.49] |
| Model 2 | 0.01 [– 0.95, 0.97] | 0.10 [– 0.78, 0.98] | Ref | 0.06 [–1.61, 1.73] |
| Model 3 | 0.16 [– 0.88, 1.2] | 0.18 [– 0.74, 1.10] | Ref | –0.23 [–2.09, 1.63] |
| 1,25(OH)2D | < 11 pg/mL | 11 – 19 pg/mL | > 20 pg/mL | log10 1,25(OH2D |
| Unadjusted | 1.26 [0.26, 2.26]* | 1.60 [0.62, 2.58]* | Ref | –1.97 [–3.68, –0.26]* |
| Model 1 | 0.07 [– 0.87, 1.01] | 0.92 [0.04, 1.80]* | Ref | 0.09 [–1.52, 1.70] |
| Model 2 | –0.17 [– 1.09, 0.75] | 0.68 [– 0.20, 1.56] | Ref | 0.50 [–1.09, 2.09] |
| Model 3 | –0.27 [– 1.29, 0.75] | 0.61 [– 0.29, 1.51] | Ref | 0.75 [–1.09, 2.59] |
| iPTH | < 109 pg/mL | 109 – 217 pg/mL | > 217 pg/mL | log10 iPTH |
| Unadjusted | –1.27 [– 2.25, –0.29]* | –1.21 [– 2.21, –0.21]* | Ref | 1.14 [0.02, 2.26]* |
| Model 1 | –0.70 [– 1.62, 0.22] | –0.74 [– 1.66, 0.18] | Ref | 0.36 [– 0.68, 1.40] |
| Model 2 | –0.71 [– 1.59, 0.17] | –0.95 [– 1.85, –0.05]* | Ref | 0.38 [– 0.62, 1.38] |
| Model 3 | –0.70 [– 1.66, 0.26] | –0.95 [– 1.89, –0.01]* | Ref | 0.29 [– 0.79, 1.37] |
| FGF-23 | < 326 Ru/mL | 326 – 1574 Ru/mL | > 1574 Ru/mL | Log10 FGF-23 |
| Unadjusted | –1.90 [– 2.9, –0.9]* | –0.56 [– 1.54, 0.42] | Ref | 1.05 [0.48, 1.62]* |
| Model 1 | –0.13 [– 1.13, 0.87] | 0.17 [– 0.75, 1.09] | Ref | 0.02 [– 0.55, 0.59] |
| Model 2 | –0.28 [– 1.26, 0.70] | –0.12 [– 1.02, 0.78] | Ref | 0.13 [– 0.44, 0.70] |
| Model 3 | –0.46 [– 5.78, 0.72] | –0.25 [– 1.25, 0.75] | Ref | 0.23 [– 0.78, 0.94] |
Model 1: age, race. Model 2: model 1, body-mass index, smoking status, years of education, homocysteine level, treatment group, diabetes, hypertension, cardiovascular disease, systolic blood pressure, diastolic blood pressure. Model 3: Model 2, calcium, phosphorus and other markers of mineral metabolism (25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, parathyroid hormone, and/or fibroblast growth factor-23, depending on variable of interest). *p < 0.05.