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. Author manuscript; available in PMC: 2015 Aug 13.
Published in final edited form as: Circ Res. 2009 Apr 16;104(10):1201–1208. doi: 10.1161/CIRCRESAHA.109.195941

Figure 6.

Figure 6

Anabolic cardiac growth and AKT signaling are not affected by FRNK expression. a, Low- and high-power images of cross-sections of 8-week-old FRNKloxp and FRNKMlc2v hearts stained with trichrome (blue corresponds to collagen) (top and middle) or with an anti–cardiac troponin T antibody (bottom). b and c, Rat neonatal cardiomyocytes were infected as described above or plated on fibronectin (FN) or collagen (COL) (10 μg/mL) and treated with IGF-1 or FGF-2 for the indicated times. Lysates were immunoblotted for phospho- and total ERK and AKT. Western data are representative of at least 3 separate experiments. See Online Figure VI for quantification.