FRNKMlc2v mice exhibit attenuated pressure overload–induced hypertrophy. a, Left ventricular (LVW) and body (BW) weight measurements were taken from control and FRNKMlc2v animals at baseline and following 14 days of transaortic constriction (TAC). Data are presented as the means±SEM (n=4/time point per genotype; *P<0.05). b, Cross-sectional myocyte area in sham and banded control and FRNKMlc2v hearts (n=at least 130 cells from 4 mice/condition; *P<0.05 compared to control banded). c, M-mode echocardiographic measurements of the left ventricle from baseline and 14-day banded control and FRNKMlc2v mice during diastole (d) and systole (s). Data are expressed as percentage of change from pre- to post-TAC. #P<0.05 when compared with percentage of change in control mice. d, Control (C) and FRNKMlc2v (F) mice were injected IP with vehicle or adrenergic cocktail for 7 minutes containing phenylephrine and isoproterenol (30 mg/kg each), and ventricular lysate was processed for Western blot analysis.