Figure 1.

A vaccine recipe (5PorA–FetA) based on that from Russell et al., 2008³⁵was used to estimate potential coverage and longevity of a PorA/FetA based recipe over a number of decades in England and Wales. (A) Potential coverage of PorA/FetA recipes³⁵ in England and Wales 1975–1995, 2000–2002 and 2010–2013 dataset with increasing number of components (PorA variable regions – VRs). (B) Theoretical amount of disease incidence prevented/present if 5PorA/FetA recipe was implemented in England and Wales 1975–2012. Isolates with an exact match to at least one of the five PorA VR1, VR2 and FetA VRs were considered to be covered by the recipe.