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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: ChemMedChem. 2014 Sep 10;9(12):2633–2637. doi: 10.1002/cmdc.201402333

Table 2.

Structures and PLD inhibitory activities of analogues 12.

graphic file with name nihms637839u2.jpg
Compd R PLD1 IC50 (nM)[a] PLD2 IC50 (nM)[a] Fold PLD2 selective
12a graphic file with name nihms637839t13.jpg 3,600 52 69
12b graphic file with name nihms637839t14.jpg 3,100 120 26
12c graphic file with name nihms637839t15.jpg >20,000 >20,000 –
12d graphic file with name nihms637839t16.jpg >20,000 >20,000 –
12e graphic file with name nihms637839t17.jpg >20,000 >20,000 –
[a]

IC50 values were determined in triplicate.