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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Bioorg Med Chem Lett. 2014 Dec 13;25(3):690–694. doi: 10.1016/j.bmcl.2014.11.082

Figure 2.

Figure 2

Structures and M5 functional assay concentration-response-curves (CRCs) obtained in the presence of a fixed acetylcholine EC80 in recombinant cells. A) rat M5 CRCs of racemic VU0652483, the active (S)-enantiomer, VU6000181 and the inactive (R)-enantiomer, VU6000180; B) human M5 CRCs of racemic VU0652483, the active (S)-enantiomer, VU6000181 and the inactive (R)-enantiomer, VU6000180; C) structures of VU0652483, VU6000181, VU6000180.