Table 2.
Multivariable logistic regression model primary outcome of HBV DNA <200 IU/ml at 24 weeks
| Univariate OR (95% CI) | Multivariate OR (95% CI) | |
|---|---|---|
| Dual vs. monotherapy (i) | 1.4 (0.6–3.0) | 1.8 (0.5–7.9) |
| Baseline CD4+ T-cell count (ii) | ||
| <70 cells/mm3 (lowest observed quartile) | 1.5 (0.6–4.0) | 14.8 (1.9–201.7) |
| 70–140 cells/mm3 (observed second quartile) | 1.0 (0.4–2.6) | 1.7 (0.3–9.6) |
| >140 cells/mm3 (above observed median) | 1.0 (ref) | 1.0 (ref) |
| Baseline AST Value (iii) | ||
| < 33 (U/L) (below observed median) | 1.0 (ref) | 1.0 (ref) |
| 33–44 (U/L) (observed third quartile) | 0.7 (0.3–1.9) | 3.1 (0.5 – 25.0) |
| >44 (U/L) (highest observed quartile) | 0.5 (0.2–1.3) | 14.1 (1.9 – 228.6) |
| Baseline HBV DNA (per 1 log10 IU/ml decrease) (iv) | 2.7 (2.0–4.0) | 4.6 (2.7–10.9) |
Forced into all models – tests for interaction terms between this comparison group and CD4 group, AST group, and HBV DNA (in separate models) were not significant.
Actual CD4 cell count entered into initial multivariable model due to association with HBV comparison group, retained by stepwise selection, and groups formed due to linearity in the logit being rejected
Actual AST value entered into initial multivariable model due to association with primary outcome, retained by stepwise selection, and groups formed due to linearity in the logit being rejected
Actual HBV DNA levels entered into initial multivariable model due to association with primary outcome, retained by stepwise selection, and linearity in the logit not rejected.
Other baseline covariates entered into initial multivariable model due to association with HBV comparison group included the following: sex, plasma HIV-1 RNA, hemoglobin, and HDV antibody. Hemoglobin removed due to collinearity.
HBeAg at baseline entered into initial multivariable model due to association with primary outcome, but was not retained in stepwise selection process.