. Author manuscript; available in PMC: 2015 Aug 13.

Published in final edited form as: J Am Chem Soc. 2009 Mar 11;131(9):3260–3270. doi: 10.1021/ja807969a

Table 2.

Kinetic Constants Defining the Activities of the Wild Type and Mutants of hTDO and xcTDO towards L-Trp

		k_cat (s⁻¹)	K_M (mM)	k_cat/K_M	reference
hTDO	Wild type	2.1	0.19	11.05	²⁴
	H76A	0.2	0.5	0.4	This work
	H76S	0.03	1.2	0.025	This work
xcTDO	Wild type	19.5	0.114	171	²¹
	H55A	2.86	0.133	21.5	²¹
	H55S	2.6	0.197	13.1	⁴⁴