Table 2.
Comparison of trough serum infliximab (IFX) levels, partial Mayo Score and C-reactive protein (CRP) levels in subgroups of ulcerative colitis patients 2 weeks after the initiation of IFX infusion
| Variable | IFX responders (n = 29) | IFX partial-responders (n = 24) | IFX non-responders (n = 19) | P1 Value | P2 Value |
|---|---|---|---|---|---|
| Trough IFX (μg/mL) | 23.3 [18.9–29.7] | 30.9 [17.7–42.7] | 25.0 [21.6–31.5] | 0.1825 | 0.4436 |
| Partial Mayo Score (0–9) | 1.0 [0–3.0] | 5.0 [3.0–6.0] | 7.0 [3.0–8.0] | <0.0001 | <0.0001 |
| CRP (mg/dL) | 0.07 [0.02–0.24] | 0.19 [0.08–0.67] | 0.43 [0.16–2.13] | 0.0135 | 0.0084 |
| CRP (week 2/week 0) ratio | 0.06 [0.02–0.21] | 0.39 [0.08–0.97] | 1.00 [0.29–1.89] | 0.0025 | <0.0001 |
Data are presented as the median [interquartile range] values and compared by Wilcoxon-Mann–Whitney test
P1, responder vs partial-responder; P2: responder vs no-responder