Table 2.
Viral load in blood and in oral and nasal swabs.
| Dose (PFU) |
Group size |
Viremiaa |
Oral swabb |
Nasal swabb |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean peak (log10 gene copy/mL) (range) |
Mean day of peak (range) |
Proportion for which peak coincided with endpoint |
Mean peak (log10 genome copies copy/mL) (range) |
Mean day of peak (range) |
Proportion for which peak coincided with endpoint |
Mean peak (log10 genome copies/mL) (range) |
Mean day of peak (range) |
Proportion for which peak coincided with endpoint |
||
| 5 × 105 | 4 | 6.05 (5.2–6.43) | 8 (7–9) | 3/3 | 7.17 (4.5–7.76) | 7.5 (6–9) | 3/4 | 6.97 (5.4–7.4) | 6.67 (3–9) | 1/3 |
| 5 × 104 | 4 | N/A | N/A | N/A | 5.5 (4.90–5.78) | 10 (9–12) | 2/2 | 6.82 (6.04–6.95) | 13 (9–21) | 1/2 |
a
Sample was not collected at necropsy for one NHP from the group that received 5 × 105 PFU of CPXV-BR.
b
Viral load was below the assay limit of detection for one NHP from the group that received 5 × 104 PFU of CPXV-BR.