TABLE 2.

Age-Adjusted Incidence Rates of AIN 3 in the San Francisco/Oakland Cancer Registry by Sex, Age Group, Race, and Calendar Period

Characteristic	Rate per 100,000 Population		RR (95% CI)	P
	2000–2004	2005–2009
Overall	2.95	5.24	1.78 (1.59–2.00)	<.001
Males	5.03	9.24	1.84 (1.62–2.08)	<.001
Age, y
20–34	1.57	3.77	2.41 (1.63–3.59)	<.001
35–49	9.96	15.24	1.53 (1.30–1.80)	<.001
50–64	5.40	13.33	2.47 (1.93–3.17)	<.001
≥65	0.95	1.97	2.08 (0.94–4.91)	.073
Race
White	5.95	10.12	1.70 (1.48–1.96)	<.001
Black	3.20	11.18	3.49 (2.14–5.85)	<.001
Other/unknown	2.78	5.90	2.13 (1.49–3.06)	<.001
Females	0.85	1.19	1.40 (1.02–1.94)	.038
Age, y
20–34	0.24	0.57	2.37 (0.83–7.63)	.123
35–44	1.34	1.41	1.05 (0.63–1.73)	.937
50–64	1.19	1.91	1.60 (0.92–2.87)	.102
≥65	0.50	0.92	1.84 (0.68–5.48)	.273
Race
White	0.86	1.24	1.45 (0.98–2.16)	.067
Black	1.77	2.26	1.28 (0.60–2.80)	.611
Other/unknown	0.42	0.66	1.57 (0.61–4.34)	.428

Abbreviation: 95% CI, 95% confidence interval; AIN 3, anal intraepithelial neoplasia 3; RR, rate ratio.