Table 1.
Characteristics of patients with lung cancer and controls in two independent groups
| Discovery group |
Validation group |
|||||||
|---|---|---|---|---|---|---|---|---|
| Patients (n = 622), n (%) |
Controls (n = 614), n(%) |
Pa | OR (95 % CI)b |
Patients (n = 615), n (%) |
Controls (n = 638), n(%) |
Pa | OR (95 % CI)b |
|
| Age (Mean ± SE) | 57.6 ± 0.5 | 58.3 ± 0.4 | 0.268 | 1.00 (0.99–1.01) | 58.1 ± 0.4 | 57.9 ± 0.4 | 0.669 | 1.00 (0.99–1.01) |
| Gender | ||||||||
| Female | 163 (26.2) | 224 (36.5) | 1 | 167 (27.1) | 231 (36.2) | 1 | ||
| Male | 459 (73.8) | 390 (63.5) | <0.001 | 1.02 (0.77–1.33) | 448 (72.9) | 407 (63.8) | 0.001 | 0.97 (0.74–1.27) |
| Smoking history | ||||||||
| No | 239 (38.4) | 407 (66.3) | 1 | 243 (39.5) | 412 (64.6) | 1 | ||
| Yes | 383 (61.6) | 207 (33.7) | <0.001 | 3.12 (2.43–1.02) | 372 (60.5) | 226 (35.4) | <0.001 | 2.83 (2.20–3.64) |
| Histologyc | ||||||||
| AC | 293 (47.1) | 302 (49.1) | ||||||
| SCC | 184 (29.6) | 167 (27.1) | ||||||
| Others | 94 (15.1) | 103 (16.8) | ||||||
| SCLC | 51 (8.2) | 43 (7.0) | ||||||
a
P values were determined using t test for age, Chi-square test for gender and smoking history
b
OR and 95 % CI were evaluated using logistic regression
c
AC adenocarcinoma, SCC squamous cell carcinoma, Others including large cell carcinoma and adeno-squamous carcinoma, SCLC small-cell lung cancer