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. Author manuscript; available in PMC: 2015 Aug 13.
Published in final edited form as: J Cancer Res Clin Oncol. 2012 Oct 2;139(2):231–242. doi: 10.1007/s00432-012-1314-z

Table 5.

Association of IL-6 promoter haplotypes with risk of lung cancer

Haplotypea Discovery group
 Validation group
Cases/controlsb OR (95 % CI)c P Cases/controlsb OR (95 % CI)c P
TC 68.5/67.1 1.00 - 67.7/66.8 1.00 -
TG 11.5/11.9 0.94 (0.73–1.22) 0.655 10.9/11.3 0.95 (0.73–1.23) 0.685
CC 6.0/3.8 1.56 (1.04–2.34) 0.031 6.3/4.1 1.51 (1.03–2.22) 0.035
CG 14.0/17.2 0.80 (0.64–1.00) 0.046 15.0/17.7 0.84 (0.67–1.04) 0.110
a

Two polymorphic alleles from left to right (-6331T>C and -572C>G) were used for haplotype reconstruction

b

Haplotype frequencies (%) of IL-6 promoter in lung cancer cases and controls

c

OR and 95 % CI were evaluated using logistic regression, adjusted for age, gender and smoking history