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. 2015 Aug 7;9:4441–4470. doi: 10.2147/DDDT.S79369

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© 2015 Niu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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The proteomic profiling of human macrophages treated with the novel NP-siRNA liposomes at 12.5 μg/mL for 24 hours determined using SILAC.

Notes: The proteomic responses of macrophages to NP-siRNA were examined using SILAC, and the pathways were analzyed by IPA. This figure shows the top pathways from the proteomic study with the threshold of 1.2 of −log(P-value) (A and B).

Abbreviations: IPA, ingenuity pathway analysis; NP, nanoparticle; SILAC, stable isotope labeling with amino acids in cell culture; siRNA, small interfering RNA.