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. 2015 Aug 7;9:4441–4470. doi: 10.2147/DDDT.S79369

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© 2015 Niu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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The ERK/MAPK signaling pathway was regulated when THP-1-derived macrophages were treated with the novel NP-siRNA liposomes at 12.5 μg/mL for 24 hours.

Notes: The proteomic response was determined by SILAC, and pathways were analyzed using IPA. Red indicates an upregulation; green indicates a downregulation. The intensity of green and red colors indicates the degree of down- or upregulation. Solid arrow indicates direct interaction, and dashed arrow indicates indirect interaction.

Abbreviations: ERK, extracellular signal-regulated kinase; IPA, ingenuity pathway analysis; MAPK, mitogen-activated protein kinase; NP, nanoparticle; SILAC, stable isotope labeling with amino acids in cell culture; siRNA, small interfering RNA.