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. 2015 Aug 7;9:4441–4470. doi: 10.2147/DDDT.S79369

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© 2015 Niu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Effects of the novel NP-siRNA liposomes on the expression levels of TGF-β1, IL-6, IL-8, TNF-α, and IFN-γ in THP-1-derived macrophages determined by ELISA.

Notes: Macrophages were cultured and treated with 12.5 μg/mL NP-siRNA liposomes, DMSO, NP-siRNA-control or medium for 24 hours. The levels of cytokines were determined using ELISA. LPS was included as the positive control. Data are the mean ± SD of three independent experiments. *P<0.05; **P<0.01; and ***P<0.001 by one-way ANOVA followed by Tukey’s post hoc test.

Abbreviations: ANOVA, analysis of variance; DMSO, dimethyl sulfoxide; IFN, interferon; IL, interleukin; ELISA, enzyme-linked immunosorbent assay; LPS, liposaccharide; NP, nanoparticle; SD, standard deviation; siRNA, small interfering RNA; TGF-β1, transforming growth factor-β1; TNF-α, tumor necrosis factor-α.