Table 2.
The top eleven upstream proteins regulated by the novel NP-siRNA liposomes in THP-1-derived macrophages
| Upstream regulator | P-value of overlap | Predicted activation state |
|---|---|---|
| APP | 5.87×10−17 | |
| CD3 | 4.90×10−3 | Inhibited |
| CD437 | 1.50×10−5 | Inhibited |
| HSF1 | 3.89×10−6 | Inhibited |
| MAPT | 1.90×10−18 | |
| MYC | 2.30×10−12 | Activated |
| MYCN | 1.16×10−12 | Activated |
| PSEN1 | 1.40×10−15 | |
| Sirolimus | 3.77×10−11 | Inhibited |
| TGF-β1 | 4.82×10−5 | |
| TNF-α | 1.27×10−4 |
Abbreviations: APP, β-amyloid (A4) precursor protein; CD3, T-cell surface glyco-protein; CD437, a cell-permeable, selective agonist of retinoic acid receptor; HSF1, heat shock transcription factor 1; MAPT, microtubule-associated protein tau; MYC, v-myc avian myelocytomatosis viral oncogene homologue; MYCN, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homologue; PSEN1, presenilin 1; TGF-β1, transforming growth factor-β1; TNF-α, tumor necrosis factor-α.