Table 3.
The upregulated and downregulated proteins involved in TGF-β1-mediated signaling pathway in THP-1-derived macrophages treated with the novel NP-siRNA liposomes at 12.5 μg/mL for 24 hours
| ID | Gene in dataset | Prediction (based on expression direction) | Fold changea | Findingsb |
|---|---|---|---|---|
| P68104 | EEF1A1 | Affected | 1.676 | Regulated (1) |
| Q13509 | TUBB3 | Activated | 1.638 | Upregulated (3) |
| B7Z6Z4 | MYL6 | Activated | 1.465 | Upregulated (1) |
| Q01469 | FABP5 | Activated | 1.402 | Upregulated (1) |
| P06753 | TPM3 | Activated | 1.392 | Upregulated (9) |
| P28482 | MAPK1 | Activated | 1.310 | Upregulated (4) |
| P00558 | PGK1 | Inhibited | 1.262 | Downregulated (1) |
| P16070 | CD44 | Inhibited | 1.261 | Downregulated (3) |
| E9PK25 | CFL1 | Activated | 1.155 | Upregulated (1) |
| P06396-2 | GSN | Inhibited | 1.142 | Downregulated (2) |
| Q01518 | CAP1 | Activated | 1.072 | Upregulated (2) |
| P50552 | VASP | Activated | 1.031 | Upregulated (2) |
| P26038 | MSN | Activated | 1.012 | Upregulated (1) |
| P07900-2 | HSP90AA1 | Activated | 1.005 | Upregulated (1) |
Notes:
The value indicates the ratio of heavy over light signal.
The number in the brackets indicates the number of proteins involved.
Abbreviations: CAP1, CAP, adenylate cyclase-associated protein 1 (yeast); CD44, CD44 molecule (Indian blood group); CFL1, cofilin 1 (nonmuscle); EEF1A1, eukaryotic translation elongation factor 1 α1; FABP5, fatty acid binding protein 5 (psoriasis-associated); GSN, gelsolin; HSP90AA1, heat shock protein 90 kDa α (cytosolic), class A member 1; MAPK1, mitogen-activated protein kinase 1; MSN, moesin; MYL6, myosin, light chain 6, alkali, smooth muscle and nonmuscle; PGK1, phosphoglycerate kinase 1; TPM3, tropomyosin 3; TUBB3, tubulin, β3 class III; VASP, vasodilator-stimulated phosphoprotein.