Table 1.
Functional enrichment analysis of genes whose expression was altered by the (thio)xanthone derivatives (P-value < 0.0001).
| FunCat ID | Category | P-value |
|---|---|---|
| TX129 (induced genes) | ||
| 32.01.01 | Oxidative stress response | 1.99E − 05 |
| 32.05.01 | Resistance proteins | 4.82E − 05 |
| 32.07 | Detoxification | 1.28E − 05 |
| TX34 (induced genes) | ||
| 1 | Metabolism | 2.21E − 14 |
| 01.05 | C-compound and carbohydrate metabolism | 2.84E − 05 |
| 01.06 | Lipid, fatty acid and isoprenoid metabolism | 2.01E − 08 |
| 20.01.01 | Ion tranport | 8.37E − 05 |
| 20.01.01.01 | Cation transport (H+, Na+, K+, Ca2 +, NH4 +, etc.) | 2.28E − 05 |
| 20.03.22 | Transport ATPases | 2.48E − 07 |
| 20.09.16.01 | Type I protein secretion system (ABC-type transport systems) | 4.96E − 06 |
| 32.05.01 | Resistance proteins | 1.51E − 05 |
| 34.01 | Homeostasis | 5.09E − 05 |
| 34.01.01 | Homeostasis of cations | 2.33E − 05 |
| 34.01.01.01 | Homeostasis of metal ions (Na, K, Ca etc.) | 1.96E − 06 |
| XP13 (induced genes) | ||
| 1 | Metabolism | 1.29E − 07 |
| 01.05 | C-compound and carbohydrate metabolism | 6.58E − 06 |
| 2 | Energy | 1.42E − 06 |
| 20.01.01 | Ion transport | 6.58E − 06 |
| 20.01.27 | Drug/toxin transport | 1.07E − 05 |
| 20.03.22 | Transport ATPases | 4.32E − 07 |
| 20.03.25 | ABC transporters | 7.67E − 05 |
| 20.09.16.01 | Type I protein secretion system (ABC-type transport systems) | 3.16E − 05 |
| 32 | Cell rescue, defense and virulence | 3.78E − 09 |
| 32.01.01 | Oxidative stress response | 2.01E − 07 |
| 32.07 | Detoxification | 1.92E − 13 |
| 32.07.05 | Detoxification by export | 5.63E − 06 |
| 32.07.07 | Oxygen and radical detoxification | 2.07E − 05 |
| XP13 (repressed genes) | ||
| 10 | Cell cycle and DNA processing | 2.54E − 07 |
| 10.03 | Cell cycle | 1.57E − 05 |
| 10.03.01 | Mitotic cell cycle and cell cycle control | 8.94E − 06 |
| 11 | Transcription | 4.17E − 13 |
| 11.02 | RNA synthesis | 9.80E − 08 |
| 11.02.03 | mRNA synthesis | 4.04E − 06 |
| 11.02.03.04 | Transcriptional control | 4.06E − 07 |
| 11.04 | RNA processing | 1.47E − 05 |
| 11.04.01 | rRNA processing | 1.43E − 07 |
| 16.03 | Nucleic acid binding | 3.42E − 05 |
| 18.02.05 | Regulator of G-protein signaling | 9.64E − 05 |
| 20.09 | Transport routes | 6.46E − 05 |