Table 3.
Annotation details of genes that are repressed (*) and induced (#) by all of the tested (thio)xanthone derivatives.
| Gene | Annotation a | Conserved domains a | Observations a | STS [24]b | PHS [25]c | MENA [26]d |
|---|---|---|---|---|---|---|
| NCU04907 | Hypothetical protein | Methyltransferase domain | Oxidative stress | Down | Down | Down |
| NCU00999 | Hypothetical protein | |||||
| NCU07235 | Hypothetical protein | Down | ||||
| NCU11307 | CCC1 | VIT family | Iron homeostasis; vacuolar iron transporter; oxidative stress | Down | Up | |
| NCU09020 | Hypothetical protein | C4-dicarboxylate transporter/malic acid transport protein | Down | |||
| NCU09428 | Hypothetical protein | Oxidative stress | Down | Down | ||
| NCU04910 | Hypothetical protein | Methyltransferase domain | Oxidative stress | Down | Down | Down |
| NCU11922 | Hypothetical protein | Also annotated as NCU16555 | Down | Down | ||
| NCU02098 | G/U mismatch-specific DNA glycosylase | Uracil DNA glycosylase superfamily; Mismatch-specific thymine-DNA glycosylate | Base-excision repair; oxidative stress | Down | ||
| NCU09830 | ABC multidrug transporter | ABC transporter | Oxidative stress | Up e |
STS: staurosporine, PHS: phytosphingosine, MENA: menadione.
a
N. crassa database at the Broad Institute (www.broadinstitute.org/annotation/genome/neurospora/MultiHome.html).
b
The dataset was obtained by RNA-seq.
c
The dataset was obtained by microarray analysis.
d
The dataset was obtained by digital gene expression profiling.
e
NCU09830 was the gene with the highest induction by menadione.