Table 4.
Risk of Schizophrenia | Risk of Bipolar Disorder | Risk of Schizoaffective Disorder | |||||||
---|---|---|---|---|---|---|---|---|---|
Exposed | Unexposed | RRs (CIs) | Exposed | Unexposed | RRs (CIs) | Exposed | Unexposed | RRs (CIs) | |
n (%) | n (%) | n (%) | |||||||
First-degree relatives | |||||||||
Parents | 26 (0.19) | 114 (0.09) | 2.2 (1.5–3.4) | 38 (0.28) | 207 (0.16) | 1.8 (1.3–2.5) | 11 (0.08) | 54 (0.04) | 2.0 (1.1–3.6) |
Children | 125 (0.39) | 750 (0.24) | 1.6 (1.4–2.0) | 248 (0.77) | 1512 (0.48) | 1.6 (1.4–1.9) | 60 (0.19) | 403 (0.13) | 1.5 (1.1–1.9) |
Full siblings | 114 (0.51) | 533 (0.24) | 2.1 (1.7–2.6) | 138 (0.62) | 728 (0.33) | 1.9 (1.6–2.2) | 39 (0.18) | 262 (0.12) | 1.5 (1.1–2.0) |
All first-degree relatives | 265 (0.39) | 1397 (0.21) | 1.9 (1.6–2.1) | 424 (0.63) | 2447 (0.37) | 1.7 (1.6–1.9) | 110 (0.16) | 719 (0.11) | 1.5 (1.2–1.8) |
Second-degree relatives | |||||||||
Maternal half-siblings | 18 (0.41) | 102 (0.29) | 1.3 (0.8–2.2) | 27 (0.61) | 142 (0.40) | 1.6 (1.1–2.3) | 4 (0.09) | 47 (0.13) | 0.6 (0.2–1.6) |
Paternal half-siblings | 18 (0.32) | 143 (0.32) | 0.9 (0.6–1.5) | 23 (0.41) | 160 (0.36) | 1.3 (0.8–1.9) | 7 (0.13) | 48 (0.11) | 1.1 (0.5–2.4) |
All half-siblings | 37 (0.37) | 253 (0.27) | 1.3 (0.9–1.8) | 52 (0.51) | 380 (0.41) | 1.3 (1.0–1.7) | 11 (0.11) | 98 (0.11) | 1.0 (0.5–1.8) |
All second-degree relativesa | 329 (0.47) | 2399 (0.35) | 1.4 (1.2–1.5) | 342 (0.49) | 2758 (0.40) | 1.2 (1.1–1.4) | 121 (0.17) | 1008 (0.15) | 1.2 (1.0–1.4) |
Third-degree relatives | |||||||||
Cousins | 149 (0.20) | 1091 (0.15) | 1.4 (1.2–1.6) | 258 (0.34) | 2049 (0.27) | 1.3 (1.1–1.4) | 70 (0.09) | 511 (0.07) | 1.4 (1.1–1.7) |
Note: Abbreviations are explained in the first footnote to table 1. Statistically significant RRs are highlighted in bold.
aSecond-degree relatives include half-siblings, grandparents, grandchildren, uncles/aunts, and nephews/nieces.