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. 2014 Nov 24;127(3):924–927. doi: 10.1002/ange.201408113

Figure 5.

Figure 5

Two-stage binding of cPDS (5 μm) and BG4 (50 nm) to the TERRA G-quadruplex. A) Folding kinetics of the TERRA G-quadruplex in solutions without ligands (black) or with cPDS+BG4 (red). The purple data points depict the folding kinetics of the species with rupture force>43 pN in the presence of both BG4 and cPDS. B) Folding rate constants (kfold) of TERRA G-quadruplexes under different conditions. C) Schematic of the proposed two-stage binding. The formation rate constant for G-quadruplex is indicated by the thickness of each arrow.