Table 2.
Trials comparing early fungicidal activity of induction treatment regimens for cryptococcal meningitis
| Induction Regimen | EFA | ± SD | n | Source |
|---|---|---|---|---|
| Amphotericin | −0.31 | 0.15 | 99 | (23) |
| Amphotericin + 5FC | −0.42 | 0.10 | 100 | |
| Amphotericin + fluconazole (800 mg/day) | −0.32 | 0.10 | 99 | |
| Amphotericin + 5FC | −0.41 | 0.22 | 21 | (28) |
| Amphotericin + fluconazole (800 mg/day) | −0.38 | 0.18 | 22 | |
| Amphotericin + fluconazole (1200 mg/day) | −0.41 | 0.35 | 23 | |
| Amphotericin + voriconazole | −0.44 | 0.20 | 13 | |
| Amphotericin (5 days) + fluconazole (1200mg/day) | −0.30 | 0.11 | 30 | (29) |
| Amphotericin + 5FC | −0.49 | NA | 30 | (34) |
| Amphotericin + 5FC + INF-γ | −0.64 | NA | 60 | |
| Amphotericin (7 days) + fluconazole (1200 mg/day) | −0.38 | 0.20 | 19 | (30) |
| Amphotericin (7 days) + fluconazole (1200 mg/day) + 5FC | −0.50 | 0.15 | 18 | |
| Fluconazole (1200 mg/day) | −0.18 | 0.11 | 30 | (38) |
| Fluconazole (800 mg/day) | −0.07 | 0.17 | 30 | |
| Amphotericin (1 mg/kg/day) | −0.48 | 0.28 | 49 | (39) |
| Fluconazole (400 mg/day) | −0.02 | 0.05 | 5 | |
| Amphotericin + fluconazole (800mg/day) | −0.36 | 0.25 | 223 | (45) |
| Amphotericin + fluconazole (800mg/day) + sertraline | −0.44 | 0.39 | 113 | (49) |
Abbreviations: EFA = early fungicidal activity (log10 CFU/mL CSF/day) calculated by linear regression except for Day et al which is calculated with mixed regression model (23); amphotericin B deoxycholate 0.7 or 1 mg/kg/day or as indicated; 5FC = flucytosine (25 mg/kg 4 times daily); Voriconazole (300 mg twice daily; 400 mg twice on day 1); INF-γ = interferon-gamma (100 μg subcutaneously, 2 or 6 doses).