Table 4.
Age–sex adjusted analysis for prediction of CMD in T2DM patients
| Independent CMD OR (CI 95 %) p value |
Dependent CMD OR (CI 95 %) p value |
|
|---|---|---|
| Age (year) | 1.06 (1.01–1.12) p 0.01* | 0.98 (0.94–1.02) p 0.55 |
| Female sex (%) | 3.24 (1.24–9.14) p 0.01* | 1.36 (0.90–1.02) p 0.23 |
| BMI (kg/m2) | 1.06 (0.99–1.48) p 0.07 | 0.96 (0.52–1.24) p 0.25 |
| GFR MDRD (ml/min) | 1.00 (0.98–1.02) p 0.49 | 0.97 (0.95–0.99) p 0.04* |
| Risk factors | ||
| Hypertension (%) | 1.16 (0.43–3.27) p 0.75 | 1.27 (0.52–3.26) p 0.59 |
| Triglycerides (mg/dl) | 1.00 (0.99–1.00) p 0.87 | 0.99 (0.99–1.00) p 0.61 |
| Diabetes control | ||
| HBA1c (%) | 1.21 (0.94–1.59) p 0.13 | 0.88 (0.67–1.12) p 0.32 |
| HBA1c < 7% | 0.60 (0.23–1.46) p 0.26 | 0.99 (0.43–2.24) p 0.98 |
| Fasting glucose (mg/dl) | 1.00 (0.99–1.01) p 0.67 | 0.99 (0.98–1.00) p 0.20 |
| Medication | ||
| Nitrates | 1.50 (0.61–3.76) p 0.36 | 0.59 (0.26–1.36) p 0.22 |
| Lipid lowering | 1.21 (0.48–3.07) p 0.68 | 1.22 (0.53–2.80) p 0.63 |
CMD coronary microvascular dysfunction, BMI body mass index, GFR glomerular filtrate rate, CFR coronary flow reserve, CRF < 2.5 independent CMD, CBFAch<50 % endothelial dependent CMD.
* Statistically significant.