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. 2015 Aug 13;4:10. doi: 10.1186/s13630-015-0019-8

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© Cognard et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Generating the Bbs10 ^−/− mouse model. a Schematic representation of the targeting strategy for Bbs10 allele. b Genotyping PCR results for homozygous knock out (Bbs10 ^−/−), heterozygous (Bbs10 ^+/−), wild-type (Bbs10 ^+/+) mice. PCR bands at 475 and 238 bp correspond to the excised allele and to the natural allele, respectively. (bp base pairs). c Relative mRNA expression levels of Bbs10 in kidneys and the eyes of Bbs10 ^+/+ and Bbs10 ^−/−. Reference gene Gapdh (n = 4 per genotype).