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. 2015 Aug 13;4:10. doi: 10.1186/s13630-015-0019-8

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© Cognard et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Bbs10^−/− mice but not Bbs10 ^fl/fl ; Cadh16-Cre ^+/− mice display polyuria associated with increased circulating AVP concentrations. a Urinary volume (µL) under 24-h fluid deprivation of Bbs10 ^+/+ and Bbs10 ^−/− mice (n = 6 per genotype). b Relative mRNA expression levels of Aqp2, Aqp3 and Avpr2 in Bbs10 ^+/+ and Bbs10 ^−/− kidneys. Gene of reference Gapdh. c Entire photographs of immunoblots for AQP2, AVPR2 and β-tub in kidneys of Bbs10 ^+/+ and Bbs10 ^−/−. d AVP plasma levels in Bbs10 ^+/+ and Bbs10 ^−/− under 24-h fluid restriction or in normal conditions. (n = 5 per genotype). e Urinary volume (µL) under 24-h fluid deprivation of Bbs10 ^fl/fl ; Cadh16Cre ^+/− and control Bbs10 ^+/+ ; Cadh16Cre ^+/− littermates (n = 6 per genotype). f Relative mRNA expression levels of Aqp2, Aqp3 and Avpr2 in Bbs10 ^+/+ ; Cadh16Cre ^+/− and Bbs10 ^fl/fl ; Cadh16Cre ^+/−. g Entire photographs of the immunoblots for AQP2, AVPR2 and β-tubulin (β-tub) in kidneys of Bbs10 ^+/+ ; Cadh16Cre ^+/− and Bbs10 ^fl/fl ; Cadh16Cre ^+/−; the immunoblots are shown in Additional file 4: Figure S4A, B. h AVP plasma levels in Bbs10 ^fl/fl ; Cadh16Cre ^+/− and control Bbs10 ^+/+ ; Cadh16Cre ^+/− under 24-h fluid restriction or in normal conditions. (n = 5 per genotype). Values are expressed as mean ± SEM. *p < 0.05.