Table 5.
Univariate and multivariate associations between patient characteristics, subgroups and anti-dementia drug use
| Variable | AChEI only | Memantine only | AChEI + memantine | |||
|---|---|---|---|---|---|---|
| Univariate | Multivariatea | Univariate | Multivariatea | Univariate | Multivariatea | |
| OR (95 % CI) | OR (95 % CI) | OR (95 % CI) | OR (95 % CI) | OR (95 % CI) | OR (95 % CI) | |
| Age (years) | 1.02 (1.00 to 1.04) | 1.04 (1.01 to 1.06) | 1.03 (1.00 to 1.07) | 1.05 (1.02 to 1.08) | 0.99 (0.96 to 1.01) | |
| Female sex | 1.06 (0.78 to 1.43) | 1.48 (0.93 to 2.33) | 1.00 (0.67 to 1.48) | |||
| ADL score | 1.03 (1.02 to 1.03) | 1.03 (1.02 to 1.04) | 1.01 (1.01 to 1.02) | 1.02 (1.01 to 1.03) | 1.02 (1.01 to 1.03) | 1.02 (1.02 to 1.04) |
| Residential care | 0.31 (0.24 to 0.40) | 1.37 (1.04 to 1.80) | 1.13 (0.79 to 1.56) | |||
| NPS subgroups | ||||||
| Hyperactivity | 0.83 (0.61 to 1.12) | 0.91 (0.60 to 1.38) | 1.69 (1.17 to 2.45) | 2.03 (1.36 to 3.04) | ||
| Psychosis | 1.15 (0.73 to 1.97) | 1.24 (0.67 to 2.26) | 1.93 (1.16 to 3.23) | |||
| Mood symptoms and apathy | 1.66 (1.22 to 2.25) | 1.44 (1.03 to 2.02) | 1.87 (1.24 to 2.83) | 1.77 (1.15 to 2.72) | 1.91 (1.30 to 2.80) | 1.56 (1.03 to 2.34) |
ADL score = Barthel Index, scale 0–100
AChEI Acetylcholinesterase inhibitor, NPS Neuropsychiatric symptoms, OR odds ratio, CI confidence interval
aForward selection. Variables included in the multivariate model are shown