Table 2.

Microarray miRNA expression analysis between tumor and control NPC FFPE tissue using unpaired Student's t-test (p-value < 0.05 and fold-change > 2.0). In this repeated analysis by GeneSpring updated nomenclature found in miRBase v19.0 was utilized to update the sample set found in [1]. Thirty-five miRNAs were dysregulated comprising four EBV specific miRNAs.

Systematic name	FC	Log FC	Regulation	Active sequence	Chromosome	miRBase accession no.
ebv-miR-BART4-3p	99.86	6.64	Up	ACACCTGGTGCCTAC	–	MIMAT0009204
ebv-miR-BART5-5p	69.01	6.11	Up	CGATGGGCAGCTATA	–	MIMAT0003413
ebv-miR-BART6-3p	92.81	6.54	Up	TCTAAGGCTAGTCCGAT	–	MIMAT0003415
ebv-miR-BART6-5p	99.86	6.64	Up	CCTATGGATTGGACCAA	–	MIMAT0003414
hsa-let-7b-5p	− 2.09	− 1.06	Down	AACCACACAACCTACTACC	chr22	MIMAT0000063
hsa-miR-100-5p	− 2.92	− 1.55	Down	CACAAGTTCGGATCTACGG	chr11	MIMAT0000098
hsa-miR-106b-5p	2.13	1.09	Up	ATCTGCACTGTCAGCAC	chr7	MIMAT0000680
hsa-miR-125b-5p	− 2.20	− 1.14	Down	TCACAAGTTAGGGTCTC	chr11	MIMAT0000423
hsa-miR-1260a	2.27	1.18	Up	TGGTGGCAGAGGTGG	chr14	MIMAT0005911
hsa-miR-1274a_v16.0	2.94	1.56	Up	TGGCGCCTGAACAG	chr5	MIMAT0005927
hsa-miR-1274b_v16.0	2.44	1.29	Up	TGGCGCCCGAACA	chr19	MIMAT0005938
hsa-miR-1275	− 3.38	− 1.76	Down	GACAGCCTCTCCCC	chr6	MIMAT0005929
hsa-miR-130b-3p	2.18	1.12	Up	ATGCCCTTTCATCATTGC	chr22	MIMAT0000691
hsa-miR-133b	− 688.84	− 9.43	Down	TAGCTGGTTGAAGGGGACC	chr6	MIMAT0000770
hsa-miR-141-3p	4.93	2.30	Up	CCATCTTTACCAGACAG	chr12	MIMAT0000432
hsa-miR-149-5p	7.11	2.83	Up	GGGAGTGAAGACACGGAG	chr2	MIMAT0000450
hsa-miR-15b-5p	2.05	1.03	Up	TGTAAACCATGATGTGCTGC	chr3	MIMAT0000417
hsa-miR-17-3p	8.90	3.15	Up	CTACAAGTGCCTTCAC	chr13	MIMAT0000071
hsa-miR-17-5p	2.44	1.29	Up	CTACCTGCACTGTAAGC	chr13	MIMAT0000070
hsa-miR-18a-5p	13.99	3.81	Up	CTATCTGCACTAGATGCA	chr13	MIMAT0000072
hsa-miR-195-5p	− 6.00	− 2.59	Down	GCCAATATTTCTGTGCTGC	chr17	MIMAT0000461
hsa-miR-196b-5p	47.26	5.56	Up	CCCAACAACAGGAAACTACC	chr7	MIMAT0001080
hsa-miR-199a-3p	− 2.65	− 1.41	Down	TAACCAATGTGCAGACTACT	chr1	MIMAT0000232
hsa-miR-199b-5p	− 3.96	− 1.99	Down	GAACAGATAGTCTAAACACTGG	chr9	MIMAT0000263
hsa-miR-203a	41.64	5.38	Up	CTAGTGGTCCTAAACATT	chr14	MIMAT0000264
hsa-miR-20a-5p	2.18	1.13	Up	CTACCTGCACTATAAGCAC	chr13	MIMAT0000075
hsa-miR-221-3p	4.19	2.07	Up	GAAACCCAGCAGACAATGT	chrX	MIMAT0000278
hsa-miR-25-3p	2.28	1.19	Up	TCAGACCGAGACAAGTGC	chr7	MIMAT0000081
hsa-miR-3138	− 2.31	− 1.21	Down	ACTCCCTCTACCTCACT	chr4	MIMAT0015006
hsa-miR-3651	3.06	1.62	Up	TCATGTACCAGCGACC	chr9	MIMAT0018071
hsa-miR-3663-3p	− 2.55	− 1.35	Down	GCGCCCGGCCT	chr10	MIMAT0018085
hsa-miR-451a	− 6.12	− 2.61	Down	AACTCAGTAATGGTAACGGTTT	chr17	MIMAT0001631
hsa-miR-486-5p	− 3.90	− 1.96	Down	CTCGGGGCAGCTCA	chr8	MIMAT0002177
hsa-miR-497-5p	− 5.17	− 2.37	Down	ACAAACCACAGTGTGCTG	chr17	MIMAT0002820
hsa-miR-93-5p	3.28	1.71	Up	CTACCTGCACGAACAG	chr7	MIMAT0000093