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. 2015 Aug 13;10(8):e0134346. doi: 10.1371/journal.pone.0134346

Fig 4. Expression levels and mutation status of tumor suppressor pathway genes.

Fig 4

(A) Integrated analysis of mRNA Expression, Mutations, and Copy Number was performed for genes in the TP53 and RB1 tumor suppressor pathways. Gene-level expression (FPKM) values for pathway member genes are presented and relative gene expression for each gene across the panel of PDX models is indicated by the heatmap (green = lower than the median, red = greater than the median). Mutations (amino acid changes) in TP53 and RB1 are indicated. Gene copy numbers are presented, and variants indicated as losses (i.e., < 2) or gains (i.e., > 2) shown by darker shades of red and green, respectively. (B) Expression levels (FPKM) of tumor suppressor pathway genes in each PDX are shown in the bar graph.