Table 3. Clinical, laboratory and echocardiographic parameters for patients divided according to TRV <2.5 and ≥2.5 m/s. eGFR, estimated glomerular filtration rate.
| TRV <2.5 m/s | TRV ≥2.5 m/s | P value | |
|---|---|---|---|
| Clinical parameter | |||
| Number of patients | 78 | 44 | |
| Age, years | 35±13 | 39±14 | 0.1 |
| Female gender (%) | 49(64) | 30(65) | 0.93 |
| Pulmonary embolism (%) | 3 (4) | 7 (15) | 0.03 |
| Regular blood transfusion (%) | 6 (7) | 8 (17) | 0.11 |
| Hydroxyurea therapy (%) | 10 (13) | 8 (17) | 0.53 |
| Mean blood pressure, mmHg | 85±11 | 82±11 | 0.24 |
| Oxygen saturation, % | 96±3 | 94±5 | 0.02 |
| Laboratory markers | |||
| Haemoglobin, g/dl | 9.9±2.0 | 8.1±1.6 | <0.01 |
| Reticulocyte count, x10-3/ μl | 303±151 | 309±127 | 0.81 |
| Lactate dehydrogenase, IU/l | 326±117 | 441±153 | <0.01 |
| Bilirubin, μmol/l | 50±38 | 50±33 | 0.97 |
| eGFR, ml/min | 87±29 | 90±28 | 0.74 |
| Proteinuria (%) | 13 (17) | 21 (45) | <0.01 |
| Echocardiographic parameters | |||
| TAPSE, cm | 2.3±0.4 | 2.5±0.4 | 0.01 |
| RV free wall E/E’ ratio | 5.4±1.8 | 5.8±2.4 | 0.43 |
| Cardiac index, L/min/m2 | 3.2±1.2 | 3.7±1.2 | 0.06 |
| LV end-diastolic volume index, ml/m2 | 67 ± 22 | 79 ± 26 | 0.01 |
| LV ejection fraction, % | 61±6 | 61±8 | 0.92 |
| LV lateral wall E/E’ ratio | 6.9±2.2 | 7.9±2.5 | 0.06 |