Table 1. Target enrichment in distinct KEGG pathways.
| Term | KEGGID | Pvalue | # Genes (observed) | # Genes (total) |
|---|---|---|---|---|
| Cell cycle | 04110 | 2.55E-09 | 45 | 123 |
| Axon guidance | 04360 | 1.87E-08 | 45 | 130 |
| DNA replication | 03030 | 4.93E-07 | 18 | 35 |
| Ribosome biogenesis in eukaryotes | 03008 | 1.23E-06 | 28 | 74 |
| RNA transport | 03013 | 2.62E-06 | 46 | 156 |
| Oocyte meiosis | 04114 | 2.93E-06 | 36 | 111 |
| p53 signaling pathway | 04115 | 4.46E-06 | 25 | 66 |
| Neurotrophin signaling pathway | 04722 | 9.54E-05 | 36 | 128 |
| GnRH signaling pathway | 04912 | 0.000208 | 29 | 99 |
| Progesterone-mediated oocyte maturation | 04914 | 0.000252 | 26 | 86 |
| Purine metabolism | 00230 | 0.000799 | 40 | 162 |
| Glioma | 05214 | 0.000992 | 20 | 65 |
| Homologous recombination | 03440 | 0.001101 | 11 | 27 |
| ErbB signaling pathway | 04012 | 0.001802 | 24 | 87 |
| Gap junction | 04540 | 0.001802 | 24 | 87 |
| Prostate cancer | 05215 | 0.002513 | 24 | 89 |
| Mismatch repair | 03430 | 0.003019 | 9 | 22 |
| VEGF signaling pathway | 04370 | 0.003324 | 21 | 76 |
| One carbon pool by folate | 00670 | 0.004161 | 8 | 19 |
| Focal adhesion | 04510 | 0.004651 | 44 | 199 |
Negatively associated miRNA targets are significantly retrieved in enriched KEGG pathways calculated based on the amount of observed and the total amount of genes. Only the top 20 terms with p-values < 0.01 are depicted.