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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Mol Carcinog. 2015 Apr 1;54(9):669–678. doi: 10.1002/mc.22301

Figure 3.

Figure 3

Nutrients are metabolized to small molecular weight compounds which increase tumoricidal activity of NK cells and induce the controlling properties of iTreg cells. The modulating effects of nutrients on the expression and function of iTreg cells are critical to prevent autoimmunity and allergy. When the gut epithelium is transformed by external stimuli including reactive oxygen species (ROS), pathogens, and inflammatory molecules, iTreg cells lose their stability and function. However, the role of these iTreg cells in tumor microenvironment remains unclear.