Table 6.
Pharmacokinetics of 15 and 40 after ip administration in mice
| Parametera | Compound 15
|
Compound 40
|
||||
|---|---|---|---|---|---|---|
| Plasma | Liver | Spleen | Plasma | Liver | Spleen | |
| AUC (μM·h) | 15.7 | 7.14 | ||||
| t1/2 (h) | 9.3 | 2.1 | ||||
| Cmax (μM)b | 1.4 | 25.3 (8.51) | 26.6 (11.4) | 2.15 | 20.2 (0.54) | 16.5 (0.18) |
| Tmax (h) | 0.5 | 0.25 | ||||
| Vz/F (L/kg) | 22.3 | 1.15 | ||||
| Mic t1/2 (min)c | 88 | 42 | ||||
a
AUC, the area under the concentration–time curve from time zero to time infinity. Cmax and Tmax, maximum concentration and time to reach Cmax. t1/2, terminal half-life. Vz/F, apparent volume of distribution.
b
Values represent compound concentrations in liver and spleen at 4 h (at 12 h) post dose.
c
In vitro mouse liver microsomal half-life.