Table 3. Association between baseline statin use and prostate cancer risk, by race/ethnicity.
| Non-Hispanic Black | Non-Hispanic White | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Cohort N (%) |
Cases N (%) |
Fully Adjusteda | Cohort N (%) |
Cases N (%) |
Fully Adjusteda | p-interaction | |||
|
|
|
||||||||
| HR | 95% CI | HR | 95% CI | ||||||
| ALL CASES | |||||||||
|
| |||||||||
| Statin Use (2-level) | |||||||||
| No Use | 19,264 (89.7) | 357 (84.8) | 1.00 | Ref | 7,231 (78.2) | 86 (65.7) | 1.00 | Ref | 0.41 |
| Use | 2,215 (10.3) | 64 (15.2) | 0.81 | 0.56, 1.17 | 2,017 (21.8) | 45 (34.4) | 1.00 | 0.64, 1.57 | |
| Statin Use (3-level)b | |||||||||
| No High Cholesterol | 16,746 (78.5) | 298 (71.1) | 1.00 | Ref | 5,761 (64.4) | 70 (56.5) | 1.00 | Ref | 0.55 |
| High Cholesterol, Statin Use | 2,181 (10.2) | 64 (15.3) | 0.81 | 0.60, 1.09 | 1,870 (20.9) | 40 (32.3) | 0.89 | 0.57, 1.38 | |
| Untreated High Cholesterol | 2,418 (11.3) | 57 (13.6) | 1.05 | 0.78, 1.42 | 1,311 (14.7) | 14 (11.3) | 0.76 | 0.41, 1.41 | |
|
| |||||||||
| HIGH-GRADE TUMORS | |||||||||
|
| |||||||||
| Statin Use (2-level) | |||||||||
| No Use | 19,182 (89.7) | 72 (84.7) | 1.00 | Ref | 7,203 (78.2) | 14 (70.0) | 1.00 | Ref | 0.81 |
| Use | 2,200 (10.3) | 13 (15.3) | 0.65 | 0.29, 1.44 | 2,006 (21.8) | 6 (30.0) | 0.56 | 0.17, 1.83 | |
|
| |||||||||
| LOW-GRADE TUMORS | |||||||||
|
| |||||||||
| Statin Use (2-level) | |||||||||
| No Use | 19,182 (89.7) | 203 (84.9) | 1.00 | Ref | 7,203 (78.2) | 44 (61.1) | 1.00 | Ref | 0.13 |
| Use | 2,200 (10.3) | 36 (15.1) | 0.82 | 0.49, 1.35 | 2,006 (21.8) | 28 (38.9) | 1.35 | 0.76, 2.42 | |
ABBREVIATIONS: 95% CI (95% Confidence Interval); HR (hazard ratio)
a
Adjusted for age, race/ethnicity, enrollment source, household income, insurance coverage, time since last doctor visit, history of prostate specific-antigen screening, history of digital rectal exam, history of high cholesterol, and family history of prostate cancer.
b
Excludes those taking other cholesterol-lowering medications, leaving 30,287 non-Hispanic black and non-Hispanic white men, among whom 543 cases occurred