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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Surgery. 2015 Jun 9;158(3):819–826. doi: 10.1016/j.surg.2015.04.017

Figure 5. JQ1 inhibited tumor growth in vivo.

Figure 5

(A) Subcutaneous neuroblastoma xenografts were established with BE(2)-C cells injected in the scapular regions of athymic nude mice. A representative photo is shown at 12 days post-treatment demonstrating tumor growth inhibition with JQ1 (right panel). (B) Tumor volume of xenografts of mice treated with daily injections (i.p.) of JQ1 (50 mg/kg/day) or vehicle (CON; 10% DMSO in 5% dextrose). Data are presented as the means ± SEM (n=5/group, *=p < 0.05 vs. CON). (C) Tumor explant and total body weights were measured at sacrifice, 12 days post-treatment with JQ1 (50 mg/kg/day; n=5/group, *=p < 0.05 vs. CON). (D) Representative immunohistochemistry of tumor sections from JQ1 and control group stained with anti-mouse vimentin and NF-L antibodies (brown stain; scale bar = 20 μm).