Withdrawal behavior was assessed during withdrawal on day 6 of week 1, 2, and 3. Data points show mean withdrawal behavior score for subjects exposed to ethanol and ORG 34517 (60 mg/kg; n=6; empty circle), ethanol and PL (60 mg/kg; n=5; filled circle), ethanol and ORG 34517 (60 mg/kg; n=6; empty circle), ethanol and PL (60 mg/kg; n=5; filled circle). Two asterisks indicate a significant week-by-diet-by-drug interaction.