Table 4.
Tests of group differences axial and radial diffusivity between 39 children with CD and 53 children with no symptoms of CD within genders and race-ethnic categories.
| Measure | Contrast | Region | MNI coordinates
|
Cluster size | Peak t | TFCE-corrected p | Cohen’s d | ||
|---|---|---|---|---|---|---|---|---|---|
| x | y | z | |||||||
| Axial diffusivity | |||||||||
| CD-HC in Females | |||||||||
| Left superior corona radiata | −16 | 7 | 33 | 6654 | 3.76 | 0.016 | 1.25 | ||
| Right superior longitudinal fasciculus | 19 | −1 | 46 | 1487 | 3.29 | 0.038 | 1.10 | ||
| Left corticospinal tract | −8 | −24 | −28 | 400 | 3.81 | 0.039 | 1.27 | ||
| Right forceps major | 22 | −63 | 35 | 115 | 3.81 | 0.049 | 1.27 | ||
| Left anterior thalamic radiation | −13 | −26 | 0 | 81 | 3.45 | 0.047 | 1.15 | ||
| Right anterior thalamic radiation | 33 | 26 | 20 | 34 | 2.53 | 0.049 | 0.84 | ||
| Left cingulum | −15 | −47 | 27 | 7 | 3.06 | 0.050 | 1.02 | ||
| Left corticospinal tract | −22 | −21 | −4 | 3 | 3.02 | 0.050 | 1.01 | ||
| CD-HC in African Americans | |||||||||
| Body of corpus callosum | −9 | −12 | 28 | 27049 | 3.48 | 0.015 | 1.45 | ||
| L superior longitudinal fasciculus | −32 | −13 | 49 | 217 | 3.11 | 0.015 | 1.30 | ||
| Radial diffusivity | |||||||||
| CD-HC | |||||||||
| Cerebellum (vermis) | −12 | −57 | −47 | 55357 | 2.67 | 0.013 | 0.62 | ||
| CD-HC in Females | |||||||||
| Cerebellum (vermis) | −14 | −56 | −40 | 69731 | 4.83 | 0.015 | 1.61 | ||
| CD-HC in African Americans | |||||||||
| Cerebellum (vermis) | −8 | −41 | −38 | 70836 | 3.05 | 0.003 | 1.27 | ||
CD: CD group (three or more symptoms of CD); HC: Healthy control group (zero symptoms of CD); TFCE = threshold-free cluster enhancement; all reported effects significant at FWE p < .05.