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. 2015 Jul 3;6(1-2):1–6. doi: 10.1007/s13317-015-0067-5

Table 2.

Time evolution of two-step strategy for NCA/ANA detection/measurement

Era Years Methods
Manual ANA IIF–reflective adding on–manual ENA 1970–2000 Manual IIF
Manual monoplex methods
Low automated monoplex methods
Manual ANA IIF–reflective adding on–automated ENA 2000–2014 Manual IIF
Full automated monoplex methods
Low automated multiplex methods
Automated ANA IIF–reflex adding on–automated ENA 2015–… Automated IIF
Full automated monoplex methods
Full automated multiplex methods

For the terminology see text