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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Clin Pharmacol Ther. 2015 May 2;98(1):25–33. doi: 10.1002/cpt.127

Figure 3.

Figure 3

Impact of eGFR on (A) oral clearance allometrically scaled to a 70 kg adult and (B) AUC0–24 dose adjusted to 0.1 mg/kg/day. The geometric mean AUC0–24 dose adjusted to 0.1 mg/kg in historical hypertensive children is shown for comparison.