Table 1.
Demographics of PK population patients by dose group
| Parameter | Lisinopril dose group
|
All (n=22) | ||
|---|---|---|---|---|
| Low dose 0.1 mg/kg (n=12) | Middle dose 0.2 mg/kg (n=8) | High dose 0.4 mg/kg (n=2) | ||
| Age (y) | 14.9 ± 2.3 | 13 ± 3 | 9.5 ± 3.5 | 13.8 ± 3.0 |
| Weight (kg) | 56.8 ± 19.4 | 50.2 ± 28.7 | 23.1 ± 3 | 51.3 ± 23.8 |
| Female | 4 (42%) | 2 (25%) | 1 (50%) | 7 (32%) |
| Race/ethnicity | ||||
| White | 7 (58%) | 2 (25%) | 2 (100%) | 11 (50%) |
| Black | 3 (25%) | 4 (50%) | 0 | 7 (32%) |
| American Indian or Alaska Native | 0 (0) | 1 (13%) | 0 | 1 (5%) |
| Not reported | 2 (17%) | 1 (13%) | 0 | 3 (14%) |
| Ethnicity | ||||
| Hispanic/Latino | 2 (17%) | 2 (25%) | 0 | 4 (18%) |
| eGFR at baseline (ml/min per 1.73m2) | 72.5 ± 25.7 (29.6, 111.2) | 62 ± 16.7 (29.2, 79.8) | 89.3 ± 44.4 (57.8, 120.6) | 70.2 ± 24.4 |
| eGFR at PK visit (ml/min per 1.73m2) | 73.1 ± 30.7 (36.7, 139.0) | 63.2 ± 18.4 (30.3, 86.0) | 100.2 ± 56.6 (60.0, 140.2) | 72.0 ± 29.4 |
| Time since transplant (years) | 4.8 ± 4.7 | 4.9 ± 3.4 | 0.9 ± 0.4 | 4.5 ± 4.1 |
Data are mean ± SD (range) or counts (%); PK, pharmacokinetic; eGFR, estimated glomerular filtration rate calculated by modified Schwartz formula (= 0.413 x length [cm]/serum creatinine [mg/dl]).