. Author manuscript; available in PMC: 2016 Jul 1.

Published in final edited form as: Clin Pharmacol Ther. 2015 May 2;98(1):25–33. doi: 10.1002/cpt.127

Table 3.

Lisinopril PK parameters dose adjusted to a 0.1 mg/kg by dose group

PK parameter	Low dose 0.1 mg/kg (n=12)	Middle dose 0.2 mg/kg (n=8)	p-value
AUC_0–24 per 0.1 mg/kg
GeoMean	365	333	0.71
95% CI	(243, 549)	(265, 419)	0.71
C_max per 0.1 mg/kg
GeoMean	26.9	24.8	0.70
95% CI	(18.4, 39.5)	(20.9, 29.5)	0.70
C₂₄ per 0.1 mg/kg
GeoMean	6.9	5.8	0.61
95% CI	(4.1, 11.7)	(3.5, 9.7)	0.61

PK, pharmacokinetic; AUC, area under the plasma concentration-time curve; GeoMean, geometric mean; CI, confidence interval; C_max, maximum observed concentration; C₂₄, concentration at 24 hours.