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. Author manuscript; available in PMC: 2016 Apr 15.
Published in final edited form as: J Immunol. 2015 Mar 16;194(8):3820–3828. doi: 10.4049/jimmunol.1301542

Figure 7. IL-18 promotes expansion of HSCs and CLPs in OP9-DL4 co-cultures.

Figure 7

Sort purified HSC (1 ×104 cells) and CLP (500 cells) from C57BL/6 mouse bone marrow were co-cultured with OP9-DL4 stromal cells in media supplemented with IL-18 or IL-7 alone or in combination and cell yields from day 7 co-cultures were measured using a hemocytometer. Data are presented as means ± SEM of three replicate wells from each experimental condition and are representative of three experiments with similar results. ** Significant with p<0.05 compared to controls and ## significant with p<0.05 compared to IL-7 or IL-18.