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. 2015 Jul 29;6:218–225. doi: 10.1016/j.redox.2015.07.013

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© 2015 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Post-translational modification of the PTEN tumor suppressor and activation of cellular Akt kinase activation in colonocytes isolated from Apc^Min/+ mice. Panel A. Immunoblot and bar graph of acrolein-PTEN adducts in the total PTEN content isolated from colonocytes of Apc^Min/+ mice or DSS-Apc^Min/+ mice treated with vehicle or resorcinol, respectively. The lower immunoblot depicts phospho-Ser⁴⁷³ Akt, a biomarker of cellular Akt activation in the same samples of colonic mucosa. Panel B. MPO activity in the mucosa of Apc^Min/+ mice or DSS-Apc^Min/+ treated with vehicle or resorcinol, respectively.