FIGURE 6.

Overlay of NTE-1, glucagon, and amylin IDE co-crystal structures. The images were generated by overlaying the published x-ray co-crystal structures of the hIDE-glucagon (2G49) and hIDE·amylin complexes (2G48) with the hIDE-NTE-1 structures reported in this work. For clarity, the hIDE proteins have been removed. The resolved portions of the hormone carbon backbones are shown as a thin line. NTE-1 is shown as a thick line (carbon, magenta; nitrogen, blue; oxygen, red). Atoms of glucagon or amylin that overlap (CPK rendering) with NTE-1 are shown as thick lines. A, NTE-1-glucagon overlay; B, NTE-1-amylin overlay.