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. 2015 Jun 19;290(33):20185–20199. doi: 10.1074/jbc.M115.667279

FIGURE 3.

FIGURE 3.

Properties of hSMN·Gemin2 complexes. A, SEC-MALS of hSMN·Gemin2 at 20 °C. The Mw values measured across the sizing peak range from ∼200 to 600 kDa. A leading shoulder contains high molecular weight aggregates. B, SV analyses of hSMN·Gemin2. The complex sediments as a 11–12 S peak at 25 °C but a 5–6 S peak at 4 °C. C, SEC-MALS of SMNΔ5·Gemin2 at 20 °C. Mw values range from ∼200–400 kDa. D, SV analyses of SMNΔ5·Gemin2. The complex sediments as a 11 S peak at 25 °C but as 4.5 S and 5.9 S species at 4 °C. See also Table 1.